ea0009oc31 | Oral Communication 4: Steroids | BES2005
Barr M
, Wilkinson D
, Holloway C
, Miller S
, MacKenzie S
, Kazi S
, Fraser R
, Connell J
, Davies E
Up to 15% of unselected patients with hypertension have evidence of inappropriate aldosterone production, identified by a raised ratio of plasma aldosterone to renin (ARR), suggesting that altered regulation of aldosterone synthesis is a key intermediate phenotype in essential hypertension. We previously described an association between the -344C/T 5'UTR polymorphism in the CYP11B2 (aldosterone synthase) gene and hypertension with raised ARR; the same genetic variation associa...